Cisplatin — properties and clinical application

Chemotherapy is one of the basic methods cancer treatment, which uses compounds with a broad spectrum activity. Among diverse group cytostatic drugs, platinum derivatives play an important role in therapy, including cisplatin. Cisplatin first generation drug approved medicine 1980s. The mechanism anti-tumor activity cisplatin based on pro-apoptotic and antiproliferative Cisplatin, through formation appropriate adducts DNA, damages structure molecule. Currently, used treatment numerous malignant neoplasms. Despite high therapeutic efficacy, has many side effects, may include, among others: ototoxicity, cardiotoxicity, neurotoxicity, hepatotoxicity nephrotoxicity. A significant problem therapy also development resistance cells to action this drug. cell depends factors. Organ toxicity induced by limit pharmacological dose its efficacy. Therefore, studies are still being conducted assess effect combined interaction other chemotherapeutic agents anticancer potential.